Design and Optimization in Organic Synthesis
Rolf Carlson (Eds.)
This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques.
The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling.
The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment.
Categorie:
Anno:
1992
Edizione:
3
Casa editrice:
Elsevier Science
Lingua:
english
ISBN 10:
0080868355
ISBN 13:
9780444892010
Collana:
Data Handling in Science and Technology 8
File:
PDF, 6.74 MB
IPFS:
,
english, 1992
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